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Compounded Semaglutide
Semaglutide is a GLP-1 medication for weight management. Compounded semaglutide is prepared by a licensed pharmacy for an individual patient. Here is how it compares with the brands and how we keep your care safe.
The basics
What is compounded semaglutide?
Semaglutide activates the GLP-1 receptor to reduce appetite and slow stomach emptying. The FDA-approved brands are Wegovy® (chronic weight management) and Ozempic® and Rybelsus® (type 2 diabetes), made by Novo Nordisk. In the STEP 1 trial, adults taking semaglutide 2.4 mg lost an average of 14.9% of their body weight over 68 weeks.
Compounded semaglutide is prepared by a licensed pharmacy on a physician’s prescription for an individual patient. Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness or quality.
Compare
Semaglutide vs tirzepatide
| Feature | Semaglutide | Tirzepatide |
|---|---|---|
| How it works | GLP-1 receptor | GIP and GLP-1 receptors |
| Brand names | Wegovy®, Ozempic®, Rybelsus® | Zepbound®, Mounjaro® |
| Average weight loss in head-to-head trial (SURMOUNT-5, 72 weeks) | 13.7% | 20.2% |
| Our programs | Oral semaglutide: $799 for a 3-month supply | From $399/month |
Regulation
Where compounded semaglutide stands with the FDA
The FDA announced on February 21, 2025 that the semaglutide shortage was resolved. Its temporary flexibility for compounding ended on April 22, 2025 for state-licensed (503A) pharmacies and on May 22, 2025 for outsourcing facilities (503B).
503A pharmacies may still compound semaglutide for an individual patient on a valid prescription, but not as "essentially a copy" of an approved product. On April 30, 2026, the FDA also proposed not to include semaglutide on the list of bulk substances that 503B outsourcing facilities may use. Your physician will explain the options available to you, including brand-name medication.
Dosing
How semaglutide dosing works
Injectable semaglutide for weight management is typically started at 0.25 mg once weekly and increased every 4 weeks (0.5 mg, 1 mg, 1.7 mg) to a maintenance dose of up to 2.4 mg, as tolerated. Oral semaglutide is taken once daily on an empty stomach with a small sip of water, at least 30 minutes before food, drink or other oral medicines. Always follow your label and your physician’s instructions.
Important safety information
Warning: risk of thyroid C-cell tumors. In rodent studies, tirzepatide caused thyroid C-cell tumors. It's unknown whether it causes these tumors, including medullary thyroid carcinoma (MTC), in people. Don't use tirzepatide if you or a family member have had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Serious side effects can include pancreatitis, gallbladder problems, low blood sugar (especially with insulin or a sulfonylurea), kidney problems, serious allergic reactions and vision changes in people with type 2 diabetes. Common side effects include nausea, diarrhea, vomiting, constipation, stomach pain and indigestion. Not for use during pregnancy. Full Prescribing Information
Pricing
How much does tirzepatide cost?
Self-pay pricing with no insurance needed. Every program includes visits with licensed physicians and your medication. No membership fees, and you can cancel anytime.
Tirzepatide
$399/month
Billed monthly
All-inclusive weight loss program with prescription GLP-1 medication (e.g. Mounjaro®, Zepbound™).
- Visits with licensed physicians
- Monthly supply of medication
- No membership fees
- Cancel subscription anytime
Packages are available at discounted rates. Brand-name medications are available at additional cost.
Get startedTirzepatide – 3 Month Package
$1,125/3 months
That’s $375/month
All-inclusive program with prescription GLP-1 medication (e.g. Mounjaro®, Zepbound™).
- Visits with licensed physicians
- 3-month supply of medication
- No membership fees
- Cancel subscription anytime
This offer cannot be combined with any other discount codes or promotions.
Get started- Best value
Tirzepatide – 6 Month Package
$2,199/6 months
That’s $366.50/month
All-inclusive program with prescription GLP-1 medication (e.g. Mounjaro®, Zepbound™).
- Visits with licensed physicians
- 6-month supply of medication
- No membership fees
- Cancel subscription anytime
More programs
- Free Consultation – Weight LossTalk to a licensed physician about your goals and whether GLP-1 treatment fits.
Free
- Oral TirzepatidePrescription oral tirzepatide to balance your metabolism and appetite.
$399/month
- Oral SemaglutidePrescription oral semaglutide to balance your metabolism and appetite.
$799/3-month supply
- Weight Loss Program MembershipDoctor-facilitated weight loss program.
$75/membership
Brand-name medications are available at additional cost. Compounded medications are not FDA-approved and have not been reviewed by the FDA for safety, effectiveness or quality.
FAQ
Common questions
Is compounded semaglutide the same as Wegovy?
It contains the same active ingredient but is not the same product. Compounded semaglutide is not FDA-approved and was not studied in the STEP trials.
Should I choose semaglutide or tirzepatide?
In the SURMOUNT-5 trial, tirzepatide led to more weight loss on average (20.2% vs 13.7%). Semaglutide may suit people who prefer an oral option or have tolerated it well before. Your physician helps you decide.
Can I switch from semaglutide to tirzepatide?
Often, yes, under a physician’s guidance. Don’t take two GLP-1 medications at the same time.
Sources (5)
- FDA: FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize
- FDA (April 30, 2026): FDA proposes to exclude semaglutide, tirzepatide and liraglutide from the 503B bulks list
- Wilding JPH et al. Once-weekly semaglutide in adults with overweight or obesity (STEP 1). N Engl J Med. 2021
- Aronne LJ et al. Tirzepatide as compared with semaglutide for the treatment of obesity (SURMOUNT-5). N Engl J Med. 2025
- Wegovy® (semaglutide) Prescribing Information, Novo Nordisk
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